Enhanced dissolution rate of diclofenac by solid dispersion method

Avik Kumar Saha, Subhabrata Banerjee, Indrani Das, MD. Farque Ansari, Kaushik Mukherjee*

Dr. B C Roy College of Pharmacy and AHS, Durgapur , 713206.

Corresponding author: kaushik.pharmacyju08@gmail.com

ABSTRACT

The objective of this work was to improve aqueous solubility of poorly water soluble drugs by a modified porous starch as solid dispersion carrier. The yield of the porous starch was found to be 80%. The flow property of the prepared porous starch was found to be good, with good compressibility index. Drug content of all the formulations were found to be in the range between 90-100%. The dissolution profile showed that in solid dispersions prepared by physical mixing process and solvent evaporation method, the dissolution of pure diclofenac is high in comparison with the solid dispersion samples. Whereas in solid dispersions prepared by solvent evaporation method, dissolution of pure diclofenac is very low in comparison with the solid dispersion samples of drug with porous starch due to co-habitation of carriers with diclofenac that improved the dissolution rate of the drug. The predicted drug release mechanism for solvent evaporation method where the drug release could be by first order release model. Thus this study confirmed that a porous starch can be developed and utilized as a carrier to improve the aqueous solubility of poorly water soluble BCS class II drugs thereby improving its dissolution rate and bioavailability.

Keywords: Porous starch, diclofenac, solid dispersion, solubility.