Recent trends on controlled release preparation of anti-epileptic drugs Lakshmikanta Ghosh1, Hirak Kumar Mukhopadhyay 1, 2*, Chandi Charan Kandar 2, Sanjoy Kumar Das 2, Bijan Kumar Gupta 1 1Department of Pharmaceutical Technology, Jadavpur University, Kolkata – 700 032, W.B., India. 2Institute of Pharmacy, Jalpaiguri, P.O. + Dist. – Jalpaiguri, 735 101, W.B., India. Running Title: Controlled release preparation and anti-epileptic drugs *Corresponding Author: E-mail: hirakju@yahoo.com Phone: +91 9434491615 Fax: +91 3561-221884 ABSTRACT In the past few decades considerable interest has been shown in the advancement of drug delivery systems. Research has been carried out to overwhelm the shortcomings of immediate release preparations. As a result, the concept of novel drug delivery system has come out which provides desired concentration of drug in the system for a long period to a target site. The research scientists are usually using different polymers as wall materials and various types of preparation procedures like, spray-drying and spray-congealing, solvent-evaporation, solid-dispersion, supercritical fluid technology, polymerization, gelation technique etc. for designing such extended release formulations. The diseases like epilepsy, diabetes, cancer, arthritis etc. require long term therapy and as a result repeated administration of immediate release preparation for long time leads to various untoward effects. Epilepsy is a chronic CNS disorder resulting from abnormal, excessive or hypersynchronous neuronal activity in the brain and sometimes associated with recurrent and unprovoked seizure. Though several anti-epileptic drugs (AED) are available but complete control of seizures with the existing conventional dosage forms of these drugs are in question because of their side effects and thus poor adherance to anti-epileptic drug therapy for long period. A number of research works have pointed out that the sustained release preparations of AEDs may be beneficial over conventional immediate release preparations with respect to delivery, bioavailability, release profile, toxicity, target specificity etc. The objective of our present study is thus to highlight the recent research work undertaken on controlled release preparation of available anti-epileptic drugs. Keywords: Anti-epileptic drugs, controlled release preparation, epilepsy, method of technique,